A FAMILIAR STUDY ON SELF-LIMITED CHILDHOOD EPILEPSY PATIENTS USING HIPSC-DERIVED NEURONS SHOWS A BIAS TOWARDS IMMATURITY AT THE MORPHOLOGICAL, ELECTROPHYSIOLOGICAL AND GENE EXPRESSION LEVELS

Abstract Background Self-limited Childhood Epilepsies are the most prevalent epileptic syndrome in children.Its pathogenesis is unknown.In this disease, symptoms resolve spontaneously in approximately 50% of patients when maturity is reached, prompting to a maturation problem.The purpose of this study was to understand the molecular bases of this d

BackgroundFunctional interactions between immune cells and neoplastic cells in the tumor immune microenvironment have been actively pursued for both biomarker discovery for patient stratification, as well as therapeutic anti-cancer targets to improve clinical outcomes.Although accumulating evidence indicates that intratumoral infiltration of immune

The active sites of multisubunit RNA polymerases have a "trigger loop" (TL) that multitasks in substrate selection, catalysis, and translocation.To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants en masse.Three mutant classes, revealed by phenotyp

Extracorporeal membrane oxygenation (ECMO) has been used successfully in critically ill patients with traumatic lung injury and offers an additional treatment modality.ECMO is mainly used as a bridge treatment to delayed surgical management; however, only a few case reports have presented the successful application of ECMO as intraoperative support

The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood.We identified Dustpan a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020.In the first episode, patients manifested an enhanced innate response compared w